منابع مشابه
NBS1 Heterozygosity and Cancer Risk
Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by chromosome instability and hypersensitivity to ionising radiation (IR). Epidemiological data evidence that the NBS1 gene can be considered a susceptibility factor for cancer development, as demonstrated by the fact that almost 40% of NBS patients ha...
متن کاملHeterozygosity for the BLM Mutation and Cancer Risk
Bloom syndrome is an autosomal recessive disorder whose characteristics include an increased risk for many types of cancers. In contrast to the homozygous mutations of Bloom syndrome, heterozygous carriers of BLM mutations may be at increased risk for developing colorectal cancer. We have screened 2,333 Jewish individuals, including 497 individuals with colorectal cancer, 125 with adenomatous p...
متن کاملNBS1 Mutation and prognosis of prostate cancer
Inherited factors contribute to the burden of prostate cancer, however the identification of susceptibility genes for prostate caner has been challenging. To establish the contribution of eight founder alleles in three DNA damage repair genes (BRCA1, CHEK2 and NBS1) to prostate cancer in Poland, and to measure the impact of these variants on survival among patients, 3750 men with prostate cance...
متن کاملNBS1 is a prostate cancer susceptibility gene.
To evaluate whether an inactivating mutation in the gene for the Nijmegen breakage syndrome (NBS1) plays a role in the etiology of prostate cancer, we compared the prevalence of the 657del5 NBS1 founder allele in 56 patients with familial prostate cancer, 305 patients with nonfamilial prostate cancer, and 1500 control subjects from Poland. Loss of heterozygosity analysis also was performed on D...
متن کاملLoss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2008
ISSN: 1389-2029
DOI: 10.2174/138920208784533610