NBS1 Heterozygosity and Cancer Risk

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چکیده

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NBS1 Heterozygosity and Cancer Risk

Biallelic mutations in the NBS1 gene are responsible for the Nijmegen breakage syndrome (NBS), a rare autosomal recessive disorder characterized by chromosome instability and hypersensitivity to ionising radiation (IR). Epidemiological data evidence that the NBS1 gene can be considered a susceptibility factor for cancer development, as demonstrated by the fact that almost 40% of NBS patients ha...

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NBS1 is a prostate cancer susceptibility gene.

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ژورنال

عنوان ژورنال: Current Genomics

سال: 2008

ISSN: 1389-2029

DOI: 10.2174/138920208784533610